Maternal floor infarction mfi is an uncommon placental disease associated with recurrent third trimester fetal loss and intrauterine growth retardation iugr usually severe.
Maternal floor infarction wikipedia.
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The pathology is a diffuse increase in peri inter villous fibrinoid and usually with some intervillous thrombi.
Placenta maternal floor infarction.
In this study of mfi and the related placental disorder massive perivillous fibrin deposition mfd semiquantitative histologic criteria for these diagnoses are defined and rates of iugr and recurrence are assessed.
In october shortly after i found out the diagnosis of maternal floor infarction massive perivillous fibrin deposition basically huge clots formed around the villi the little fingerlike placental protusions that delivered nutrients to luke making them unable to function i connected with the folks over at the star legacy foundation the only national u s.
It is moot whether such a lesion which i will call true maternal floor infarction occurs but the term maternal floor infarction is not usually used in this sense.
The disorder is somewhat misnamed because it is characterized by heavy deposition of fibrin in the decidua beneath the placenta rather than by arterial occlusion.
Micrograph of a placental infarct.
By now everyone agrees that maternal floor infarction is a misnomer at least for most of the cases so labeled.
It is formally known as placental maternal floor infarction it is also known as massive perivillous fibrin deposition.
The disease is characterized by extensive fibrin deposition in the intervillous spaces.
Maternal floor infarction mfi is a poorly understood placental lesion reportedly associated with intrauterine growth restriction iugr and recurrence.
In an attempt to determine the frequency course and outcome of maternal floor infarcts 39 215 placentas and pregnancies were reviewed.
Small placental infarcts especially at the edge of the placental disc are considered to be normal at term large placental infarcts are associated with vascular abnormalities e g.
A placental infarction results from the interruption of blood supply to a part of the placenta causing its cells to die.
A maternal floor infarction then should show fibrin or matrix thickening of the maternal surface with otherwise typical changes of infarction in the villi.
This website is intended for pathologists and laboratory personnel but not for patients.
